HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 1-(4-Methoxybenzyl)-5-(4,5-dimethoxy-2-nitrobenzoyl)-1,2,3-triazole-4-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Ethyl 1-(4-methoxybenzyl)-5-(4,5-dimethoxy-2-nitrobenzoyl)-1,2,3-triazole-4-carboxylate | HCID 22222563 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 1-(4-Methoxybenzyl)-5-(4,5-dimethoxy-2-nitrobenzoyl)-1,2,3-triazole-4-carboxylic acid | HCID 22222572 | — |
Reaction Steps
In the same manner as above, a solution of ethyl 1-(4-methoxybenzyl)-5-(4,5-dimethoxy-2-nitrobenzoyl)-1,2,3-triazole-4-carboxylate (b-2) (3.12 g, 6.63 mmole) in tetrahydrofuran (100 ml) was hydrolyzed with a 1N aqueous sodium hydroxide solution (13 ml) at room temperature for 3.5 hours to give 1-(4-methoxybenzyl)-5-(4,5-dimethoxy-2-nitrobenzoyl)-1,2,3-triazole-4-carboxylic acid (c-2': MP) (2.32 g, 79%)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05840895 |
| Source dataset | uspto-grants-1998_11 |
| ORD ID | ord-323ee8a0d3ed4b3982a969e37234ffe4 |
| Source note | uspto-grants-1998_11 |