Formic Acid → 2,3,4,5-Tetrafluorobenzoyl chloride

HRID 357696Notes

Reaction equation

HRID 357696 reaction equation
[F:1][C:2]1[C:7]([F:8])=[C:6]([F:9])[C:5]([F:10])=[CH:4][C:3]=1[C:11]([Cl:14])(Cl)Cl.C(O)=[O:16]>[Fe](Cl)(Cl)Cl>[F:1][C:2]1[C:7]([F:8])=[C:6]([F:9])[C:5]([F:10])=[CH:4][C:3]=1[C:11]([Cl:14])=[O:16]

Participants

4

Reactant 2

HCID 284Formic AcidHCID 153460071,2,3,4-Tetrafluoro-5-(trichloromethyl)benzene

Product 1

HCID 27336892,3,4,5-Tetrafluorobenzoyl chlorideYield 93%

Reagents, catalysts & solvents 1

HCID 24380Iron chloride (FeCl3)Catalyst

Procedure

268 g of 2,3,4,5-tetrafluorobenzotrichloride were added to the distillation residue (approximately 20 g) and 2.7 g of iron(III) chloride were added. The mixture was reacted with formic acid in a similar manner to a). 198 g (93% of theory) of 2,3,4,5-tetrafluorobenzoyl chloride were obtained.

Workup

  1. additionwere added

Sources & evidence

ORD record
ord-76bc8db7a9d645798fdff6f4ae650862
Source dataset
uspto-grants-1998_11
Patent number
US05840975

Reaction notes

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