HCID 57239133, compound → HCID 18938078, compound

HRID 357728Notes

Reaction equation

HRID 357728 reaction equation
[NH2:1][P:2]([NH2:15])([NH:4][C:5](=[O:14])[CH:6]=[CH:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)=[O:3]>CO>[NH2:1][P:2]([NH2:15])([NH:4][C:5](=[O:14])[CH2:6][CH2:7][C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=1)=[O:3]

Participants

3

Reactant 1

HCID 57239133HCID 57239133, compound

Product 1

HCID 18938078HCID 18938078, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

N-(Diaminophosphinyl)cinnamamide (1 g) was dissolved in methanol (200 ml), and 10% Pd--C (wet) (0.4 g) was added. The mixture was hydrogenated at room temperature under atmospheric pressure for 30 minutes, and the catalyst was removed by filtration and the filtrate was concentrated under reduced pressure. The precipitated crystals were collected by filtration, washed with diethyl ether and recrystallized from methanol to give the desired compound.

Workup

  1. customthe catalyst was removed by filtration
  2. concentrationthe filtrate was concentrated under reduced pressure
  3. filtrationThe precipitated crystals were collected by filtration
  4. washwashed with diethyl ether
  5. customrecrystallized from methanol

Sources & evidence

ORD record
ord-2079362c158d4cb1a618a9ce5112868e
Source dataset
uspto-grants-1998_11
Patent number
US05840917

Reaction notes

Loading…