反应详情

温度

40 °C

A mixture of 2-chloro-3-thiophenecarboxylic acid (2.44 g), pyridinium bromide perbromide (5.33 g) and acetic acid (15 ml) was stirred at 40° C. for 4 hours and poured into ice-water. Precipitated crystals were collected by filtration, dissolved in ethyl acetate and dried over anhydrous magnesium sulfate. The solution was concentrated under reduced pressure to give 5-bromo-2-chloro-3-thiophenecarboxylic acid (2.81 g) as crystals.

1. customPrecipitated crystals
2. filtrationwere collected by filtration
3. dissolutiondissolved in ethyl acetate
4. dry with materialdried over anhydrous magnesium sulfate
5. concentrationThe solution was concentrated under reduced pressure