HCID 57279834, compound → HCID 18938020, compound

HRID 357800Notes

Reaction equation

HRID 357800 reaction equation
[NH2:1][P:2]([NH2:18])([NH:4][C:5](=[O:17])[CH:6]=[CH:7][C:8]1[O:9][C:10]2[CH:16]=[CH:15][CH:14]=[CH:13][C:11]=2[N:12]=1)=[O:3]>CO>[NH2:18][P:2]([NH2:1])([NH:4][C:5](=[O:17])[CH2:6][CH2:7][C:8]1[O:9][C:10]2[CH:16]=[CH:15][CH:14]=[CH:13][C:11]=2[N:12]=1)=[O:3]

Participants

3

Reactant 1

HCID 57279834HCID 57279834, compound

Product 1

HCID 18938020HCID 18938020, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

N-(Diaminophosphinyl)-3-(2-benzoxazolyl)prop enamide (0.25 g) was dissolved in methanol (30 ml) with heating, and 10% Pd--C (wet) (0.05 g) was added. The mixture was hydrogenated at room temaperature under atmospheric pressure for 1 hour. The catalyst was removed by filtration, and the filtrate was concentrated under reduced pressure. Precipitated crystals were collected by filtration to give N-(diaminophosphinyl)-3-(2-benzoxazolyl)propinonamide (0.17 g) as colorless crystals.

Workup

  1. temperaturewith heating
  2. customThe catalyst was removed by filtration
  3. concentrationthe filtrate was concentrated under reduced pressure
  4. customPrecipitated crystals
  5. filtrationwere collected by filtration
  6. customto give N-(diaminophosphinyl)-3-(2-benzoxazolyl)propinonamide (0.17 g) as colorless crystals

Sources & evidence

ORD record
ord-fe83287277c14af29fa685f45ca438d2
Source dataset
uspto-grants-1998_11
Patent number
US05840917

Reaction notes

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