O-ethylhydroxylamine hydrochloride → 2-[1-(Ethoxyimino)butyl]-3-hydroxy-5-(6-methylsulfonyl-2,3,4,5-tetramethylphenyl)cyclohex-2-en-1-one

HRID 35786Notes

Reaction equation

HRID 35786 reaction equation
[C:1]([C:6]1[C:7](=[O:27])[CH2:8][CH:9]([C:13]2[C:18]([S:19]([CH3:22])(=[O:21])=[O:20])=[C:17]([CH3:23])[C:16]([CH3:24])=[C:15]([CH3:25])[C:14]=2[CH3:26])[CH2:10][C:11]=1[OH:12])(=O)[CH2:2][CH2:3][CH3:4].Cl.[CH2:29]([O:31][NH2:32])[CH3:30]>>[CH2:29]([O:31][N:32]=[C:1]([C:6]1[C:7](=[O:27])[CH2:8][CH:9]([C:13]2[C:18]([S:19]([CH3:22])(=[O:21])=[O:20])=[C:17]([CH3:23])[C:16]([CH3:24])=[C:15]([CH3:25])[C:14]=2[CH3:26])[CH2:10][C:11]=1[OH:12])[CH2:2][CH2:3][CH3:4])[CH3:30]

Participants

3

Reactant 2

HCID 76850O-ethylhydroxylamine hydrochlorideHCID 178450316HCID 178450316, compound

Product 1

HCID 1361402682-[1-(Ethoxyimino)butyl]-3-hydroxy-5-(6-methylsulfonyl-2,3,4,5-tetramethylphenyl)cyclohex-2-en-1-one

Procedure

2-[1-(Ethoxyimino)butyl]-3-hydroxy-5-(6-methylsulfonyl-2,3,4,5-tetramethylphenyl)cyclohex-2-en-1-one (57) was prepared from 2-butyryl-3-hydroxy-5-(6-methylsulfonyl-2,3,4,5-tetramethylphenyl)cyclohex-2-en-1-one and ethoxyamine hydrochloride following essentially the same procedure as that described in Example 1, part (iv). The product was characterized by proton nuclear magnetic resonance spectroscopy and the spectroscopic data is reported in Table 5, Example 37.

Sources & evidence

ORD record
ord-5eb06e7eed3f4943999d3ac847ea7b64
Source dataset
uspto-grants-1988_08
Patent number
US04767879

Reaction notes

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