HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-[1-(2-phenylethyl)-4-ethoxycarbonyl-5-bromopyrazol-3-yl]-N-[(2'-(N-triphenylmethyl-(1H-tetrazol-5-yl))biphenyl-4-yl)methyl]-n-propylamine → HCID 178457033, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-[1-(2-phenylethyl)-4-ethoxycarbonyl-5-bromopyrazol-3-yl]-N-[(2'-(N-triphenylmethyl-(1H-tetrazol-5-yl))biphenyl-4-yl)methyl]-n-propylamine | HCID 22103828 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 178457033 | HCID 178457033 | 87.7% |
Reaction Steps
356 mg of N-[1-(2-phenylethyl)-4-ethoxycarbonyl-5-bromopyrazol-3-yl]-N-[(2'-(N-triphenylmethyl-(1H-tetrazol-5-yl))biphenyl-4-yl)methyl]-n-propylamine were dissolved in 5 ml of ethanol and heated under reflux for 2 hours, and the solvent was distilled off under reduced pressure. The resulting residue was subjected to silica gel column chromatography (n-hexane-ethyl acetate=2:1→ethyl acetate) to obtain 224 mg of the intended compound as a pale yellow, amorphous solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05840909 |
| Source dataset | uspto-grants-1998_11 |
| ORD ID | ord-5718daef5e7148ac9709d70052b12127 |
| Source note | uspto-grants-1998_11 |