Acetic Acid → HCID 86739581, compound

Participants

Reaction Steps

700 mg of 11β-chloro-17α-ethynyl-17β-hydroxy-18-methyl-4,15-estradien-3-one in 10 ml of pyridine is reacted at room temperature with the addition of 100 mg of 4-dimethylaminopyridine with 6 ml of acetic anhydride. The mixture is introduced, after 4 hours, into ice/water which contains acetic acid. The thus-precipitated product is vacuum-filtered, dissolved in ethyl acetate, and washed with water. The crude product is chromatographed on silica gel with hexane/acetone (0-10%), thus obtaining 510 mg of 17β-acetoxy-11β-chloro-17α-ethynyl-18-methyl-4,15-estradien-3-one as a foam.

Provenance & Evidence