Chloroacetone → 8-Phenylmethoxyimidazo[1,2-b]pyridazine

HRID 358021Notes

Reaction equation

HRID 358021 reaction equation
[NH2:1][C:2]1[N:3]=[N:4][CH:5]=[CH:6][C:7]=1[O:8][CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1.Cl[CH2:17][C:18](=O)C>>[C:10]1([CH2:9][O:8][C:7]2[C:2]3[N:3]([CH:17]=[CH:18][N:1]=3)[N:4]=[CH:5][CH:6]=2)[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=1

Participants

3

Reactant 2

HCID 6571ChloroacetoneHCID 204502733-Amino-4-phenylmethoxypyridazine

Product 1

HCID 204502748-Phenylmethoxyimidazo[1,2-b]pyridazine

Procedure

For example, condensation of 3-amino-4-phenylmethoxypyridazine with chloroacetone gives an 8-phenylmethoxyimidazo[1,2-b]pyridazine with a methyl at the 2-position and a hydrogen as shown in the following reaction Scheme II: ##STR14##

Sources & evidence

ORD record
ord-538db8cb041b4ec2b75d47069a0e5f1c
Source dataset
uspto-grants-1984_08
Patent number
US04464372

Reaction notes

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