反应详情

A mixture of (0.01 mole) 3-amino-6-methyl-4-phenylmethoxypyridazine, [prepared following the methodology of Becket, et al. J. Pract. Chem., 311, 285(1969) and references cited therein], and (0.012 mole) 2-bromo-3-butanone in methanol is heated for 24 hours in a bath maintained at 100°. The mixture is cooled to room temperature and partitioned between aqueous sodium bicarbonate and methylene chloride. The layers are separated and the aqueous phase extracted with methylene chloride. The organic extracts are combined and dried over anhydrous sodium sulfate. The solvent is removed under reduced pressure to give 6-methyl-8-phenylmethoxy-2,3-dimethylimidazo[1,2-b]pyridazine.

1. custom[prepared
2. temperaturemaintained at 100°
3. custompartitioned between aqueous sodium bicarbonate and methylene chloride
4. customThe layers are separated
5. extractionthe aqueous phase extracted with methylene chloride
6. dry with materialdried over anhydrous sodium sulfate
7. customThe solvent is removed under reduced pressure