Formic Acid → HCID 20450293, compound

Participants

Reaction Steps

A solution of 0.70 g of 98% formic acid in 70 ml of dichloromethane was stirred under dry nitrogen with 2.5 g of carbonyldiimidazole for 15 minutes and 1.4 g of ethyl 4,5-dihydroimidazo[1,2-a]quinoxaline-2-carboxylate were added. The mixture was stirred at room temperature for 6 hours under nitrogen and was then poured into ice/aqueous bicarbonate and filtered. The organic layer was dried over magnesium sulfate and evaporated under reduced pressure to a low volume. Dilution with ether gave 1.1 g (70% yield) of ethyl 4-formyl-4,5-dihydroimidazo[1,2-a]quinoxaline-2-carboxylate as colorless crystals after crystallization from dichloromethane/diethyl ether.

Provenance & Evidence