Methanol → HCID 20449999, compound

Participants

Reaction Steps

A solution of 108.92 g of 5-acetamino-2-amino-2'-chlorobenzophenone in 1.4 l of ethanol is treated dropwise at room temperature with a solution of 15.9 g of sodium borohydride in 100 ml of water. The solution obtained is then heated to boiling under reflux until decolourization occurs and subsequently, after the addition of 300 ml of methanol, heated for a further 15 minutes. The organic solvents are distilled off in vacuo and the residue is suspended in 0.5 l of water. The crystals obtained are recrystallized from ethanol/water. There is obtained 5-acetamino-2-amino-2'-chlorobenzhydrol of melting point 137°-138°.

Provenance & Evidence