Ethanol → HCID 20450027, compound

HRID 358053Notes

Reaction equation

HRID 358053 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[C:14]2[CH:15]=[C:16]([NH:19]C(OCC)=O)[CH:17]=[CH:18][C:13]=2[NH:12][C:11](=[O:25])[CH2:10][CH:9]=1.C[O-].[K+].CO.C(O)C>O>[NH2:19][C:16]1[CH:17]=[CH:18][C:13]2[NH:12][C:11](=[O:25])[CH2:10][CH:9]=[C:8]([C:3]3[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=3[Cl:1])[C:14]=2[CH:15]=1

Participants

6

Reactant 4

HCID 702EthanolHCID 887MethanolHCID 20450013HCID 20450013, compoundHCID 23664618Potassium methoxide

Product 1

HCID 20450027HCID 20450027, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

13.0 g of ethyl 5-(2-chlorophenyl)-2,3-dihydro-2-oxo-1H-1-benzazepine-7-carbamate are heated to boiling under reflux for 13 hours together with 39 g of potassium methylate in a mixture of in each case 215 ml of methanol, ethanol and water. After evaporation of the organic solvents, the residue is extracted with chloroform. The residue from the chloroform extract is crystallized from ethyl acetate. There is obtained 7-amino-5-(2-chlorophenyl)-1,3-dihydro-2H-1-benzazepin-2-one of melting point 192°.

Workup

  1. customAfter evaporation of the organic solvents
  2. extractionthe residue is extracted with chloroform
  3. extractionThe residue from the chloroform extract
  4. customis crystallized from ethyl acetate

Sources & evidence

ORD record
ord-89a27e2d9fab4a418844c8b55aad9368
Source dataset
uspto-grants-1984_08
Patent number
US04464300

Reaction notes

Loading…