Hydrazine hydrate (1:1) → HCID 20449954, compound

Participants

Reaction Steps

235 mg of 8-chloro-1-(phthalimidomethyl)-6-(2-fluorophenyl)-4H-s-triazolo[4,3-a][1]benzazepine are dissolved in 15 ml of ethanol and treated with 500 ml of hydrazine hydrate. The mixture is stirred at room temperature for 2 hours and then the ethanol is evaporated in vacuo. The residue is dissolved in ethyl acetate, washed twice with water, dried and evaporated. The residue is chromatographed on 10 g of aluminium oxide (neutral, activity grade III). By elution with chloroform/ethanol (9:1) and crystallization from ethyl acetate there is obtained 1-(aminomethyl)-8-chloro-6-(2-fluorophenyl)-4H-s-triazolo[4,3-a][1]benzazepine of melting point 187°-190°.

Provenance & Evidence