Water → HCID 20449987, compound

Participants

Reaction Steps

15.0 g of 7-chloro-5-(2-fluorophenyl)-2-hydrazino-4,5-dihydro-2H-1-benzazepine are dissolved in 200 ml of dimethylformamide. After adding 18 g of N,N'-carbonyl-diimidazole, the mixture is stirred at 52° for 20 hours, poured into 2 l of water and extracted with ethyl acetate. The organic extracts are washed with water, dried and evaporated. The residue is chromatographed on 800 g of silica gel. By elution with chloroform which contains 2% ethanol and crystallization from ether there is obtained 8-chloro-6-(2-fluorophenyl)-2,4,5,6-tetrahydro-1H-s-triazolo[4,3-a][1]benzazepin-1-one of melting point 236°-238°.

Provenance & Evidence