Toluene → HCID 12354514, compound

HRID 358094Notes

Reaction equation

HRID 358094 reaction equation
[CH3:1][N:2]=[C:3]=[O:4].[C:5]1(C)[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1>>[C:5]1([N:2]2[CH2:1][C:3](=[O:4])[N:2]([CH3:1])[C:3]2=[O:4])[CH:6]=[CH:7][CH:8]=[CH:9][CH:10]=1

Participants

3

Reactant 2

HCID 1140TolueneHCID 12228Methyl Isocyanate

Product 1

HCID 12354514HCID 12354514, compoundYield 35%

Procedure

A mixture of n-phenyl glycine (22.3 grams, 0.15 moles), methylisocyanate (14.2 grams, 0.25 moles) and 30 ml of toluene was stirred at 40°-45° C. for 7 hours and allowed to stand overnight at room temperature (21° C.). The product was collected and washed with toluene, crystallized from toluene and yielded 10.5 grams (35% yield) of the above-identified product having a melting point of about 168°-170° C.

Workup

  1. waitto stand overnight at room temperature
  2. custom(21° C.)
  3. customThe product was collected
  4. washwashed with toluene
  5. customcrystallized from toluene

Sources & evidence

ORD record
ord-d9db9d504cb74300a682115dcb5b64cb
Source dataset
uspto-grants-1984_08
Patent number
US04464387

Reaction notes

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