Pyridine → HCID 13206714, compound

Participants

Reaction Steps

By following the same procedure as in Example 6 using 3.7 g of methoxymalonic acid mono-tert-butyl ester and 5 g of 2-(m-hydroxyphenyl)imidazo[2,1-b]benzothiazole, 6 g of 2-[m-(α-carboxy-α-methoxyacetoxy)phenyl]imidazo[2,1-b]benzothiazole.hydrochloride was obtained through 2-[m-(α-tert-butoxycarbonyl-α-methoxyacetoxy)phenyl]imidazo[2,1-b]benzothiazole (yield 7.3 g). Then, to 3 g of the hydrochloride were added a small amount of pyridine and 50 ml of ethyl acetate to dissolve the hydrochloride and 10% acetic acid was added to the solution, thereby crystals precipitated. The crystals thus formed were recovered by filtration, washed with isopropanol, and dried to provide 2.1 g of 2-[m-(α-carboxy-α-methoxyacetoxy)phenyl]imidazo[2,1-b]benzothiazole.

Provenance & Evidence