HCID 12926153, compound → HCID 15591923, compound

HRID 358108Notes

Reaction equation

HRID 358108 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]=[C:10]3[N:14]([CH:15]=2)[C:13]2[CH:16]=[CH:17][CH:18]=[CH:19][C:12]=2[S:11]3)=[CH:4][C:3]=1[OH:20].[CH3:21][O:22][C:23]1[CH:36]=[CH:35][C:26]([CH2:27][O:28][C:29](=[O:34])[CH2:30][C:31](O)=[O:32])=[CH:25][CH:24]=1>>[CH3:21][O:22][C:23]1[CH:24]=[CH:25][C:26]([CH2:27][O:28][C:29]([CH2:30][C:31]([O:20][C:3]2[CH:4]=[C:5]([C:8]3[N:9]=[C:10]4[N:14]([CH:15]=3)[C:13]3[CH:16]=[CH:17][CH:18]=[CH:19][C:12]=3[S:11]4)[CH:6]=[CH:7][C:2]=2[Cl:1])=[O:32])=[O:34])=[CH:35][CH:36]=1

Participants

3

Reactant 2

HCID 12926153HCID 12926153, compoundHCID 14373005HCID 14373005, compound

Product 1

HCID 15591923HCID 15591923, compoundYield 45.3%

Procedure

By following the same procedure as in Example 2 using 1.9 g of 2-(4-chloro-3-hydroxyphenyl)imidazo[2,1-b]benzothiazole and 2.7 g of malonic acid mono-p-methoxybenzyl ester, 1.05 g of 2-(3-carboxyacetoxy-4-chloro)phenylimidazo[2,1-b]benzothiazole.hydrochloride was obtained through 2-[3-(p-methoxybenzyloxycarbonylacetoxy)-4-chlorophenyl]imidazo[2,1-b]benzothiazole (yield of 1.45 g, melting point of 113°-115° C.).

Sources & evidence

ORD record
ord-526190f6c08246aa85c28441fa19183b
Source dataset
uspto-grants-1984_08
Patent number
US04464384

Reaction notes

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