HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 358124Generated: October 29, 2026
Hydrochloric Acid → 5-[(6-Chloroquinolin-2-yl)oxy]-2-nitrobenzoic acid
https://huagongshe.com/reaction/358124
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Potassium | HCID 5462222 | — |
| Reactant | HCID 6931879 | HCID 6931879 | — |
| Reactant | HCID 178515629 | HCID 178515629 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Solvent | Water | HCID 962 | — |
| Product | 5-[(6-Chloroquinolin-2-yl)oxy]-2-nitrobenzoic acid | HCID 13337869 | — |
Reaction Steps
A reactor is charged with 4.34 grams (0.02 mole) of the potassium salt of 6-chloro-2-hydroxyquinoline (Formula II Compound) in 25 milliliters of dimethylsulfoxide. To this mixture is added 4.46 grams (0.02 mole) of the potassium salt of 5-fluoro-2-nitrobenzoate (Formula III Compound). After stirring at about 100° C. for about 16 hours, the reaction mixture is poured into 200 milliliters of water and acidified with concentrated hydrochloric acid. Filtration and air drying affords 5-(6-chloro-2-quinolinoxy)-2-nitrobenzoic acid (Formula IV Compound).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04464533 |
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| Source dataset | uspto-grants-1984_08 |
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| ORD ID | ord-1bb98feec2e642abb2db4d648a58ece2 |
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| Source note | uspto-grants-1984_08 |
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