참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Dicyclohexylcarbodiimide | HCID 10868 | — |
| 반응물 | N-(tert-butoxycarbonyl)glycine | HCID 78288 | — |
| 반응물 | N-Hydroxysuccinimide | HCID 80170 | — |
| 반응물 | benzyl (2S)-2-amino-3-methylbutanoate | HCID 6950584 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | HCID 91977270 | HCID 91977270 | — |
반응 단계
44 g BocGlyOH (0.25 moles) is dissolved in 250 ml DMF, together with 29 g HOSu. After cooling to -20° C. 52 g DCC dissolved in 250 ml DMF is added. After 4 hours stirring at room temperature 95 g ValOBzl, pTos is added together with 35 ml TEA. After stirring overnight at room temperature, DCU is filtered off, DMF removed and the resulting oil taken up in EtAc and washed with sat. NaCl, sat. NaHCO, and 10% citric acid. The EtAc is dried with Na2SO4, removed by vacuum evaporation and the resulting crystalline mass dried in a desiccator. Yield: 59 g (65%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05411942 |
|---|
| 출처 데이터셋 | uspto-grants-1995_05 |
|---|
| ORD ID | ord-e87f09c186f442838b23a97ad9246f78 |
|---|
| 출처 메모 | uspto-grants-1995_05 |
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