Acetone → Diacetone L-sorbose

Participants

Reaction Conditions

Reaction Steps

To 200 ml of acetone were added 10.0 g of L-sorbose and 225 mg of N-iodosuccinimide and the mixture was refluxed with stirring in a water bath at 60° C. for 6 hours. During this reaction, the refluxing solvent was dried with 20 g of Molecular Sieves 3A interposed between the reaction vessel and the cooling jacket. The reaction mixture was then subjected to an after-treatment similar to that described in Example 11 to give 8.43 g (58.4%) of 2,3:4,6-di-O-isopropylidene-L-sorbofuranose (purity ≥97%).

Provenance & Evidence