Acetic Acid → HCID 13271641, compound

Participants

Reaction Steps

To a solution of 457 mg of 4-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)oxy-1H-imidazole-5-carboxamide in 30 ml of dry methanol was added 270 mg of 95% sodium methoxide. The reaction mixture was stirred for 20 minutes at room temperature and 0.33 ml of acetic acid was added. Chromatographical purification on LH-20 (product of Pharmacia A/S) in methanol of the residue which was obtained after evaporation of the reaction mixture under reduced pressure, gave 260 mg of 4-β-D-glucopyranosyloxy-1H-imidazole-5-carboxamide which was crystallized with acetone. m.p. 167° C. (dec.)

Provenance & Evidence