1,2,3,5-Tetraacetyl-beta-D-ribofuranose → 1-(4-nitrobenzyl)-4-(2,3,5-tri-O-acetyl-beta-D-ribofuranosyl)oxy-1H-imidazole-5-carboxamide

Participants

Reaction Steps

Following a procedure similar to that of Example 1 but using 2,3,5-tri-O-acetyl-D-ribofuranosyl chloride prepared from 2.50 g of 1,2,3,5-tetra-O-acetyl-β-D-ribofuranose and 1.022 g of 5-carbamoyl-1-(4-nitrobenzyl)imidazolium-4-olate there was obtained 0.986 g of 1-(4-nitrobenzyl)-4-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)oxy-1H-imidazole-5-carboxamide which was recrystallized from ethanol. m.p. 155.5°-156.5° C.

Provenance & Evidence