反应详情

The crude Boc-Asn-Leu-Gly-OBzl was suspended in 2.0 l 50% ethanol. Addition of 10 g 10% Palladium on carbon and hydrogenation for one hour at 3 bar hydrogen pressure under stirring. The crude solution was filtrated and pH adjusted to 3.0 with a 1N sodium hydrochloric acid solution. Removal of ethanol under vacuum at 40° C. resulted in crystallisation of product. Filtration and drying under vacuum at 40° C. for 2 days gave the pure product. Yield 72.3 g (58%).

1. filtrationThe crude solution was filtrated
2. customRemoval of ethanol under vacuum at 40° C.
3. customresulted in crystallisation of product
4. filtrationFiltration
5. customdrying under vacuum at 40° C. for 2 days
6. customgave the pure product