Acetonitrile → HCID 88720335, compound

Participants

Reaction Steps

5.5 g of 7β-[(2R)-2-(4-BOC-aminophenyl)-2-(4-ethyl-2,3-dioxopiperazine-1-carboxamido)-acetamido]-3-carbamoyloxymethyl-3-cephem-4-carboxylic acid diphenylmethyl ester are reacted in 200 ml of acetonitrile with 2.44 g of p-toluenesulphonic acid monohydrate in the manner described in Example 22. 7β-[(2R)-2-(4-Aminophenyl)-2-(4-ethyl-2,3-dioxopiperazine-1-carboxamido)-acetamido]-3-carbamoyloxymethyl-3-cephem-4-carboxylic acid diphenylmethyl ester p-toluenesulphonate is obtained. [α]D20 =+11°±1° (1.098% in CH3OH);

Provenance & Evidence