Acetonitrile → HCID 88720709, compound

Participants

Reaction Steps

3.3 g of 7β-[(2S)-2-(4-BOC-aminophenyl)-2-(4-ethyl-2,3-dioxopiperazine-1-carboxamido)-acetamido]-3-carbamoyloxymethyl-3-cephem-4-carboxylic acid diphenylmethyl ester are reacted in 100 ml of acetonitrile with 1.46 g of p-toluenesulphonic acid monohydrate in the manner described in Example 22. 7β-[(2S)-2-(4-Aminophenyl)-2-(4-ethyl-2,3-dioxopiperazine-1-carboxamido)-acetamido]-3-carbamoyloxymethyl-3-cephem-4-carboxylic acid diphenylmethyl ester p-toluenesulphonate is obtained. [α]D20 =+27°±1° (0.954% in CH3OH);

Provenance & Evidence