Sodium Hydroxide → HCID 54165014, compound

HRID 358182Notes

Reaction equation

HRID 358182 reaction equation
[OH-].[Na+].[F:3][C:4]([F:17])([F:16])[CH2:5][N:6]([CH2:14][CH3:15])[C:7](=[O:13])[CH2:8][O:9]C(=O)C>CO>[F:3][C:4]([F:16])([F:17])[CH2:5][N:6]([CH2:14][CH3:15])[C:7](=[O:13])[CH2:8][OH:9]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 13090850HCID 13090850, compound

Product 1

HCID 54165014HCID 54165014, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
20 °C

Procedure

8 ml of saturated sodium hydroxide solution were added to a solution of 20 g (0.088 mol) of N-(2,2,2-trifluoroethyl)-N-ethyl-acetoxyacetamide in 100 ml of methanol. The mixture was stirred at 20° C. for 15 hours and concentrated and the concentrate was neutralized with acetic acid and extracted with methylene chloride. The organic phase was dried and filtered. After the solvent had been distilled off, N-(2,2,2-trifluoroethyl)-N-ethylhydroxyacetic acid amide was obtained as a yellow oil. ##STR14##

Workup

  1. concentrationconcentrated
  2. extractionextracted with methylene chloride
  3. customThe organic phase was dried
  4. filtrationfiltered
  5. distillationAfter the solvent had been distilled off

Sources & evidence

ORD record
ord-d9e3d3a41a78483899f55a52b0b40838
Source dataset
uspto-grants-1984_08
Patent number
US04465504

Reaction notes

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