反应详情

A suspension of 0.8 gm of 4-(4-aminophenyl)-1-H-imidazole and 1.86 gm of ethyl N-methyl-formimidate hydrochloride [F. H. Suydam et al., J. Org. Chem. 34, 292 (1969)] in 20 ml of anhydrous ethanol was stirred at room temperature for two days. The clear solution was evaporated to dryness, and the oily residue was dissolved in water. The solution so obtained was adjusted to pH 10 with 10% NaOH. The product which separated was extracted with ethyl acetate, the organic solution was evaporated to dryness, and the product obtained was purified through its hydorchloride salt to give 0.35 gm of the desired compound as crystalline solid.

1. customThe clear solution was evaporated to dryness
2. dissolutionthe oily residue was dissolved in water
3. customThe solution so obtained
4. customThe product which separated
5. extractionwas extracted with ethyl acetate
6. customthe organic solution was evaporated to dryness
7. customthe product obtained
8. customwas purified through its hydorchloride salt