Methane → HCID 178446833, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2.3 gm of 4-(p-aminophenyl)-1-H-imidazole, 1.25 gm of t-butylisonitrile, 0.2 gm of AgCl, and 0.11 gm of imidazole was heated at 100° C. for 13 hours. The thick reaction mixture was treated with 10% HCl and ethyl acetate. The acid solution was adjusted to pH 6.5 with 10% NaOH, treated with charcoal, filtered, and adjusted to an alkaline pH. The layer which separated was extracted with ethyl acetate. After drying, the organic solution was evaporated to dryness to yield 0.38 gm of the desired compound.

Provenance & Evidence