Hydrochloric Acid → HCID 178475884, compound

Participants

Reaction Steps

To a solution of 6.1 g. of sodium salt of 7β-(3-oxo-4-methylvaleramido)-3-acetoxymethylceph-3-em-4-carboxylic acid in 60 ml. of glacial acetic acid, are dropped 2.1 g. of sodium nitrite dissolved in 20 ml. of water. After stirring for 2 hours at ambient temperature, there are added 200 ml. of ethyl acetate and 100 ml. of hydrochloric acid 0.1N. The phases are separated and the organic phase is washed with 50 ml. of water, made anhydrous, decolourised over charcoal and concentrated to small volume. The precipitated solid is filtered off to give 1.4 g of 7β-(2-hydroxyimino-3-oxo-4-methylvaleramido)-3-acetoxymethylceph-3-em-4-carboxylic acid melting at 156° C. (with decomposition); [α]D =+76.9° C. (c=2 in tetrahydrofuran/water 1:1).

Provenance & Evidence