HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl Isocyanate → N,2-Dimethyl-2,3-dihydro-1H-indole-1-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl Isocyanate | HCID 12228 | — |
| Reactant | 2-Methylindoline | HCID 23305 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | N,2-Dimethyl-2,3-dihydro-1H-indole-1-carboxamide | HCID 12321965 | 89% |
Reaction Steps
1 mole of 2-methylindoline is dissolved in 300 ml of toluene and 1 mole of methyl isocyanate is added, the temperature not rising above 25° C. The mixture is left to stand for 1 day and the resulting precipitate is then filtered off. N-Methylaminocarbonyl-2-methylindoline with a melting point of 158°-160° C. is obtained. Yield: 89% of theory.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04466964 |
| Source dataset | uspto-grants-1984_08 |
| ORD ID | ord-301534f4b203478c9dc009a74deb5d9e |
| Source note | uspto-grants-1984_08 |