Methyl chloroformate → HCID 70447670, compound

Participants

Reaction Steps

2-Amino-1,3-bis(1H-1,2,4-triazol-1-yl)-2-(2,4-dichlorophenyl)propane (0.234 g, 0.7 mmole) was added to a suspension of oil-free sodium hydride (27 mg, 1.125 mmole) in dry tetrahydrofuran (5 ml) and the mixture was stirred at room temperature for 1 hour. Methyl chloroformate (0.104 g, 1.1 mmole) was then added and the mixture was stirred at room temperature for 16 hours. The solvent was removed in vacuo and the residue dissolved in chloroform (25 ml) and then washed with water (10 ml). The organic phase was dried (MgSO4), filtered and evaporated and the residue was recrystallized from ethyl acetate to furnish the title compound as a colorless solid (48 mg, 17%), m.p. 171°-2°.

Provenance & Evidence