Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ammonia → Darodipine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ammonia | HCID 222 | — |
| 반응물 | Ethyl Acetoacetate | HCID 8868 | — |
| 반응물 | 2,1,3-Benzoxadiazole-4-carbaldehyde | HCID 10290873 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | Darodipine | HCID 51701 | — |
반응 단계
3.2 g of 2,1,3-benzoxadiazole-4-aldehyde, 5.7 g of acetoacetic acid ethyl ester, 2.5 ml of concentrated ammonia and 10 ml of ethanol are refluxed for 6 hours. The mixture is subsequently evaporated and the residual oil is chromatographed on silica gel with chloroform/acetic acid ethyl ester (9:1) to yield the title compound. The product is recrystallised from toluene, m.p. 153°-155°.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04466972 |
| 출처 데이터셋 | uspto-grants-1984_08 |
| ORD ID | ord-2ec7ca9f28604726b6a49a661f02f296 |
| 출처 메모 | uspto-grants-1984_08 |