HuagongsheHuagongshe Chemistry Print Report · For research reference only
1H-1,2,4-Triazole → Quinazoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1H-1,2,4-Triazole | HCID 9257 | — |
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | HCID 178517962 | HCID 178517962 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | Quinazoline | HCID 9210 | — |
Reaction Steps
Intermediates of formula (3) wherein L is 1,2,4-triazol-1-yl, can be prepared, for example, by adding POCl3 dropwise to a mixture of a 4-hydroxyquinazoline (1 equiv.) of formula (9) and 1,2,4-triazole (3 equiv.) in pyridine at room temperature.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05411963 |
| Source dataset | uspto-grants-1995_05 |
| ORD ID | ord-d59970963f2240559b489333de83ca79 |
| Source note | uspto-grants-1995_05 |