Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | Methyl acetoacetate | HCID 7757 | — |
| Reactant | Ammonium Hydroxide | HCID 14923 | — |
| Reactant | HCID 131713665 | HCID 131713665 | — |
| Product | Nifedipine | HCID 4485 | — |
Reaction Steps
2-Nitrobenzaldehyde-diacetate (0.1 mole, 25.4 g), methyl acetoacetate (0.2 mole, 23.2 g) and NH4OH (12 ml) were heated in methanol (20 ml) in the presence of pyridine for several (7) hours. After cooling to 15° C. the precipitated product was filtered off. The crude product was crystallized from acetic acid to yield 4-(2'-nitrophenyl)-2,6-dimethyl-3,5-dicarbmethoxy-1,4-dihydropyridine (21.7 g, 62% of the theory), m.p. 172°-174° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04467093 |
|---|
| Source dataset | uspto-grants-1984_08 |
|---|
| ORD ID | ord-b1d9957efac4496f95ba8a0c9c1ff410 |
|---|
| Source note | uspto-grants-1984_08 |
|---|
