Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Methyl acetoacetate | HCID 7757 | — |
| Reactant | Ammonium Hydroxide | HCID 14923 | — |
| Reactant | HCID 131713665 | HCID 131713665 | — |
| Product | Nifedipine | HCID 4485 | — |
Reaction Steps
2-Nitrobenzaldehyde-diacetate (0.1 mole, 25.4 g), methyl acetoacetate (0.21 mole, 26 g), NH4OH (12 ml) and methanol (45 ml) were heated under reflux for 5 hours. After cooling to 15° C. the precipitated product was filtered off. The crystallization of the crude product from acetic acid yielded 4-(2'-nitrophenyl)-2,6 dimethyl-3,5-dicarbmethoxy-1,4-dihydropyridine (19.0 g, 55% of the theory), m.p. 173°-174° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04467093 |
|---|
| Source dataset | uspto-grants-1984_08 |
|---|
| ORD ID | ord-cd45dff0420743c8985e0405aedb09ff |
|---|
| Source note | uspto-grants-1984_08 |
|---|
