反应详情

An intimate mixture of 5-(2-aminoethyl)thiomethyl-4-methylimidazole (1.28 gms) and 5-benzyl-6-methyl-2-methylthio-4-pyrimidone (1.84 gms) was heated at 150°-160° C. (oil-bath temperature) for 41/2 hours. The mixture was cooled, washed with water and recrystallised from isopropanol to give 2-[-2-(4-methyl-5-imidazolylmethylthio)ethylamino]-5-benzyl-6-methyl-4-pyrimidone (1.82 gms) m.p.=140°-141.5° C.

1. temperaturewas heated at 150°-160° C. (oil-bath temperature) for 41/2 hours
2. temperatureThe mixture was cooled
3. washwashed with water
4. customrecrystallised from isopropanol