反应详情

A mixture of 1.0 g of 4-chloroquinazoline and 2.0 g of 2-(2-naphthyl)ethyl amine was heated under nitrogen to 165°-170° C. for one hour. The mixture was cooled and then 200 ml of a 50/50 mixture of ammonium hydroxide/water was added. The product was extracted into CH2Cl2, and the resulting solution was treated with charcoal and filtered. The solution was then concentrated to dryness, and the residue was recrystallized from a mixture of pentane and CH2Cl2 to give: 0.480 g of the title product. Yield: 26.7%. M.P. 172°-174° C.

1. temperaturewas heated under nitrogen to 165°-170° C. for one hour
2. temperatureThe mixture was cooled
3. additionwas added
4. extractionThe product was extracted into CH2Cl2
5. additionthe resulting solution was treated with charcoal
6. filtrationfiltered
7. concentrationThe solution was then concentrated to dryness
8. customthe residue was recrystallized from a mixture of pentane and CH2Cl2
9. customto give