HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 358416Generated: October 30, 2026
Nitric Acid → 1-Methyl-2-nitro-3-(trifluoromethyl)benzene
https://huagongshe.com/reaction/358416
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Nitric Acid | HCID 944 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | 3-Methylbenzotrifluoride | HCID 136246 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1-Methyl-2-nitro-3-(trifluoromethyl)benzene | HCID 13455431 | — |
Reaction Steps
2 gms of 3-methyl benzotrifluoride is dissolved in 5 mls of methylene chloride and added dropwise with stirring at -20° C. to -25° C. to 6 gms of 98% HNO3 dissolved in 10 ml methylene chloride. After addition, the reaction was allowed to finish by warming the mixture to 15° C. After treatment with ice and water followed by sodium bicarbonate wash, near quantitative yield was recovered. Isomer distribution was as follows:
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04467125 |
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| Source dataset | uspto-grants-1984_08 |
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| ORD ID | ord-5b33dbfb87f8438d8104f2a811283c5e |
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| Source note | uspto-grants-1984_08 |
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