反应详情

温度

10 °C

6 gms of 90% nitric acid is cooled to -5° C. and 2 gms of 3-methyl benzotrifluoride was added dropwise with stirring. The two phase system was allowed to warm to 10° C. during addition. After stirring 2 hours, the reaction mixture was poured onto ice, extracted with methylene chloride and washed with dilute aqueous sodium bicarbonate. After vacuum removal of solvent on a rotary evaporator, near quantitative oil was obtained which had isomer distribution:

1. stirringAfter stirring 2 hours
2. additionthe reaction mixture was poured onto ice
3. extractionextracted with methylene chloride
4. washwashed with dilute aqueous sodium bicarbonate
5. customAfter vacuum removal of solvent
6. customon a rotary evaporator
7. customnear quantitative oil was obtained which