Epichlorohydrin → HCID 13239942, compound

Participants

Reaction Steps

2.1 g (6.6 mmol) of N-α-methylbenzyl-2-nitrobenzenesulfonamide was dissolved in 10 ml of epichlorohydrin, to which was gradually added at room temperature 0.35 g (7.3 mmol) of 50% sodium hydride, followed by agitating at room temperature for 30 minutes and reacting under reflux for 1 hour. The epichlorohydrin was distilled off under reduced pressure, water was added and extracted with ethyl acetate. The ethyl acetate phase was dried over anhydrous magnesium sulfate, concentrated, and purified by the silica gel chromatography to obtain the intended product (Compound No. 33). The yield was 97% and the nD26.5 value was 1.5572. The results of the elemental analysis are shown below.

Provenance & Evidence