HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl Isocyanate → 1-(Methylcarbamoyl)-3-[(4-chlorophenyl)thio]-azacycloheptan-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl Isocyanate | HCID 12228 | — |
| Reactant | Di-n-butyldilauryltin | HCID 9809426 | — |
| Reactant | HCID 13268904 | HCID 13268904 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 1-(Methylcarbamoyl)-3-[(4-chlorophenyl)thio]-azacycloheptan-2-one | HCID 20448003 | — |
Reaction Steps
25.6 g (0.1 mol) of 3-[(4-chlorophenyl)thio]-azacycloheptan-2-one together with 5.7 g (0.1 mol) of methyl isocyanate and 100 mg of dibutyl-tin dilaurate in 150 ml of absolute toluene are boiled under reflux for 5 hours. After the mixture has cooled, the solvent is stripped off in vacuo, and the oily residue is used for further reactions.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04468392 |
| Source dataset | uspto-grants-1984_08 |
| ORD ID | ord-7067370980904d529ab71b7ad55b6b99 |
| Source note | uspto-grants-1984_08 |