Ethanolamine → HCID 70456037, compound

HRID 358439Notes

Reaction equation

[C:1]([C:3](=[C:10]1[CH2:17][C@H:16]2[C@H:12]([CH2:13][CH:14]([OH:28])[C@@H:15]2/[CH:18]=[CH:19]/[C@@H:20]([OH:27])[CH:21]([CH3:26])[CH2:22][CH2:23][CH2:24][CH3:25])[O:11]1)[CH2:4][CH2:5][CH2:6][C:7](O)=[O:8])#[N:2].[CH2:29]([CH2:31][NH2:32])O>>[OH:28][CH:14]1[CH2:13][C@H:12]2[C@H:16]([CH2:17]/[C:10](=[C:3](/[CH2:4][CH2:5][CH2:6][C:7]3[O:8][CH2:29][CH2:31][N:32]=3)\[C:1]#[N:2])/[O:11]2)[C@H:15]1/[CH:18]=[CH:19]/[C@@H:20]([OH:27])[CH:21]([CH3:26])[CH2:22][CH2:23][CH2:24][CH3:25]

Participants

Reactant 2

HCID 700Ethanolamine

HCID 70455641HCID 70455641, compound

Product 1

HCID 70456037HCID 70456037, compound

Procedure

Analogously to Example 4 from 78 mg (0.2 mmol) of 5-cyano-5-{(1S,5R,6R)-7-hydroxy-6-[(E)-(3S,4RS)-3-hydroxy-4-methyl-1-octenyl]-2-oxabicyclo[3.3.0]octan-3-ylidene}-pentanoic acid and ethanolamine. Yield: 60 mg (72% of theory).

Sources & evidence

ORD record: ord-b92eafe7f8ed468889b8420c6c2a60d6
Source dataset: uspto-grants-1984_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04468395

Reaction notes

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