HuagongsheHuagongshe Chemistry Print Report · For research reference only
Aniline → 6-Benzyl-5,6-dihydro-4-hydroxy-2-methyl-1,1-dioxo-N-phenyl-2H-1,2,6-thiadiazine-3-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Aniline | HCID 6115 | — |
| Reactant | methyl 6-benzyl-5,6-dihydro-4-hydroxy-2-methyl-1,1-dioxo-2H-1,2,6-thiadiazine-3-carboxylate | HCID 54719673 | — |
| Product | 6-Benzyl-5,6-dihydro-4-hydroxy-2-methyl-1,1-dioxo-N-phenyl-2H-1,2,6-thiadiazine-3-carboxamide | HCID 54719672 | 54% |
Reaction Steps
The synthesis is effected analogously to Example 1 using in each case 1 equivalent of methyl 6-benzyl-5,6-dihydro-4-hydroxy-2-methyl-1,1-dioxo-2H-1,2,6-thia-diazine-3-carboxylate and aniline. Recrystallisation from a diisopropyl ether/acetone mixture gives the title compound in a yield of 54%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05411955 |
| Source dataset | uspto-grants-1995_05 |
| ORD ID | ord-85b34e73c2644d82b2c88c6b7e5732d4 |
| Source note | uspto-grants-1995_05 |