2-(Dimethylaminomethyl)-4-(2-aminoethylthiomethyl)thiazole → 2-[2-(2-Dimethylaminomethyl-4-thiazolylmethylthio)ethyl]amino-5-(4-pyridyl)methyl-4-pyrimidone

Participants

Role	Name	HCID	Charge
Reactant	2-(Dimethylaminomethyl)-4-(2-aminoethylthiomethyl)thiazole	HCID 10977318	—
Reactant	2-Nitroamino-5-(4-pyridyl)methyl-4-pyrimidone	HCID 13373474	—
Product	2-[2-(2-Dimethylaminomethyl-4-thiazolylmethylthio)ethyl]amino-5-(4-pyridyl)methyl-4-pyrimidone	HCID 13373488	—

Reaction Steps

Following the procedure of Example 1, 2-nitroamino-5-(4-pyridyl)methyl-4-pyrimidone was reacted with 2-(2-dimethylaminomethyl-4-thiazolylmethylthio)ethylamine to yield 2-[2-(2-dimethylaminomethyl-4-thiazolylmethylthio)ethyl]amino-5-(4-pyridyl)methyl-4-pyrimidone as a trihydrochloride salt melting at 200°-202° C. after recrystallization from a methanol/ethanol solvent mixture.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US04468399
Source dataset	uspto-grants-1984_08
ORD ID	ord-c53e3833d45846169d77f13e2b4c8e12
Source note	uspto-grants-1984_08