HCID 20448151, compound → HCID 13373503, compound

Participants

Reaction Steps

A solution of 2-(dimethylaminomethyl-4-thiazolylmethylthio)ethylamine (2.3 g) and 2-nitroamino-5-[1-(4,4'-dimethoxybenzhydryl)imidazol-4-ylmethyl]-4-pyrimidone (4.62 g) in ethanol (11 ml) was refluxed for 22 hours. Ethanol was evaporated from the solution and the residue chromatographed using HPLC. The appropriate fractions were combined and freed of solvents to give about 1.6 g of 2-[2-(2-dimethylaminomethyl-4-thiazolylmethylthio)ethyl]amino-5-[1-(4,4'-dimethoxybenzhydryl)imidazol-4-ylmethyl]-4-pyrimidone as a glass.

Provenance & Evidence