反应详情

N-Benzyloxycarbonylglycine (10.9 g, 52.2 mmol) and N-hydroxysuccinimide (6.0 g, 52.2 mmol), were dissolved in dioxane (100 ml) and cooled in a cold water bath. N,N'-Dicyclohexylcarbodiimide (10.8 g, 52.2 mmol) was added and the mixture was stirred overnight. The white precipitate which formed was filtered, washed and air-dried (11.8 g, 100% of dicyclohexylurea). The filtrate was evaporated to dryness under reduced pressure, and the residual solid (16.2 g) was crystallized from ethyl acetate (50 ml) to give 8.4 g (53%) of crystalline N-(N-benzyloxycarbonylglycyloxy)succinimide, m.p. 110.5-112° C.

1. temperaturecooled in a cold water bath
2. customThe white precipitate which formed
3. filtrationwas filtered
4. washwashed
5. dry with materialair-dried (11.8 g, 100% of dicyclohexylurea)
6. customThe filtrate was evaporated to dryness under reduced pressure
7. customthe residual solid (16.2 g) was crystallized from ethyl acetate (50 ml)