HCID 12797486, compound → HCID 20448365, compound

Participants

Reaction Steps

6.6 g. 4-[2-hydroxy-3-(N-benzylisopropylamino)-propoxy]-3-formylindole (see Example 1) are dissolved in 150 ml. methanol, mixed with 0.5 g. 10% palladiumcharcoal and hydrogenated at ambient temperature and under a hydrogen pressure of 1 bar. The reaction mixture is subsequently filtered and concentrated to a volume of about 20 ml. and the equivalent amount of benzoic acid is added thereto. After suction filtration, there are obtained 3.1 g. (44% of theory) 4-[2-hydroxy-3-(isopropylamino-propoxy]-3-formylindole benzoate; m.p. 204°-105° C.

Provenance & Evidence