Phosphorus pentachloride → 1-(4-(chloromethyl)thiazol-2-yl)-N,N-dimethylmethanamine hydrochloride

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Reaction Steps

To a 100 ml. flask were added 2.1 g. of 4-chloromethyl-4-hydroxy-2-dimethylaminomethyl-2-thiazoline and 25 ml. of 1,2-dichloroethane. To the mixture was added dropwise a solution of 2.1 g. of phosphorous pentachloride and 50 ml. of 1,2-dichloroethane, while the temperature of the mixture was held in the range 17°-25°. After the addition, the mixture was stirred for 16 hours. It was then filtered, and the filter cake was washed with 1,2-dichloroethane and dried under vacuum at 50° to obtain 2.4 g. of the desired product, which was identified by nmr analysis as being substantially identical to the product of Example 5.

Provenance & Evidence