Dichloromethane → HCID 13326550, compound

Participants

Reaction Conditions

Reaction Steps

A stirred solution of 73 ml (0.84 mole) of propionyl chloride in 250 ml of dichloromethane was cooled to 0° C. (salt-ice bath) and treated portionwise with 94.2 g (0.84 mole) of freshly distilled cyclohexanecarboxaldehyde. After further cooling to -5° C., approximately 0.5 g of zinc chloride was added. The temperature rose gradually to 7° C. as a solid separated. The cooling bath was removed and while stirring was continued the reaction mixture was allowed to warm to room temperature (the solid gradually went into solution). After about 1 hour some additional zinc chloride was added; there was no further reaction. The solution was kept overnight at room temperature.

Provenance & Evidence